Introduction. A correct diagnostic of recurrent aphthous stomatitis (RAS, sometimes also called recurrent oral ulcers or ulcers) is a central element of dentistry issues. Aphthous ulcers have been carefully defined so that they can be differentiated from many other types of recurrent oral ulcers that are not associated with systemic abnormalities (M.Kh. Ibragimova, 2019). Objectively, the prevalence rate is incredibly high, but if RAS is defined as more than two spontaneously occurring episodes per year, then the average prevalence in the population is about 10%, which seems reasonable. Many studies struggle with definitions and ask if subjects ever had mouth ulcers. Reported estimates range from 1.5 to 28% in different parts of the world according to the WHO, suggesting that there may be genetic differences that account for these geographic differences. Current evidence suggests that RAS may be the result of an abnormal cascade of cytokines in the oral mucosa, which leads to a cell-mediated immune response directed to the focal area of the oral mucosa (Alimova D.M., 2021).
Herpes viral infection (HVI) occupies one of the leading places among viral diseases in humans due to the wide spread prevalence of the virus and the ability to be persis tent perpetually in humans after a primary infection. According to the WHO, from 90 to 100% of the world's popu-lation are infected with herpes simplex viruses (HSV) of the 1st and 2nd types. Based on the results of the analysis of scientific research and scientific literature data, one can come to the conclusion that there is a need for large-scale research on this problem in Uzbekistan. The aim of research was to study of the effectiency of applying biological active additive Reptin-plant within the complex treatment of her-petic stomatitis patients and therapeutic effect of photody-namic therapy with the PDU device in patients with HSV. Under our supervision, there were 75 children diagnosed with HSV at the age of 18 to 40 years, divided into three groups, depending on the therapy. All patients were mainly treated on an outpatient basis. Analysis of the data obtained from the treatment results showed that the group of patients with HSV received complex treatment (traditional treatment + Reptin-plant + PDU) was more effective than traditional therapy alone.
An analysis of the recent literary sources indicates that one of the common diseases of the oral mucous membrane and the red border of the lips are diseases accompanied by hyper- and dyskeratosis, there are lichen planus, leukoplakia, various forms of cheilitis, known as facultative precancers, with a frequency of malignancy up to 19% (Kamilov Kh.P., Kadyrbaeva A.A., 2019). Currently, such techniques are known as stomatoscopy, photostomatoscopy, luminescence study when exposed to ultraviolet rays (Wood's rays), fluorescence diagnostics (Bulgakova N.N., 2015; Krikheli N.I., 2016)
The main goal of oral leukoplakia treatment is to detect and prevent malignancy. The first step is to stop dangerous activities such as smoking. Additional histopathological evaluation is required. The degree of dysplasia determines the choice of treatment. Oral leukoplakia can be completely ruled out when the risk of malignancy (dysplasia or simple dysplasia) is low, or other factors such as location, size, and the patient's involvement in smoking cessation should be considered in decision making. Surgical treatment is recommended for moderate to severe epithelial dysplasia.